Getting To Mars: 4 Things We’re Doing Now

Why Sequencing DNA in Space is a Big Deal

… And How You Can Talk to the Scientists Who Made It Happen

Less than one month ago, DNA had never been sequenced in space. As of today, more than one billion base pairs of DNA have been sequenced aboard the International Space Station, Earth’s only orbiting laboratory. The ability to sequence the DNA of living organisms in space opens a whole new world of scientific and medical possibilities. Scientists consider it a game changer. 

NASA astronaut Kate Rubins, who has a background in genomics, conducted the sequencing on the space station as part of the Biomolecule Sequencer investigation. A small, commercial, off-the-shelf device called MinION (min-EYE-ON), manufactured by Oxford Nanopore Technologies in the UK, was used to sequence the DNA of bacteria, a virus and rodents. Human DNA was not sequenced, and there are no immediate plans to sequence human DNA in space. 

(Image Credit: Oxford Nanopore Technologies)

The MinION is about the size of a candy bar, and plugs into a laptop or tablet via USB connection, which also provides power to the device. The tiny, plug and play sequencer is diminutive compared to the large microwave-sized sequencers used on Earth, and uses much less power. Unlike other terrestrial instruments whose sequencing run times can take days, this device’s data is available in near real time; analysis can begin within 10-15 minutes from the application of the sample.

Having real-time analysis capabilities aboard the space station could allow crews to identify microbes, diagnose infectious disease and collect genomic and genetic data concerning crew health, without having to wait long periods of time to return samples to Earth and await ground-based analysis.

The first DNA sequencing was conducted on Aug. 26, and on Sept. 14, Rubins and the team of scientists back at NASA’s Johnson Space Center in Houston hit the one-billionth-base-pairs-of-DNA-sequenced mark.

Have more questions about how the Biomolecule Sequencer works, or how it could benefit Earth or further space exploration? Ask the team of scientists behind the investigation, who will be  available for questions during a Reddit Ask Me Anything on /r/science on Wednesday, Sept. 29 at 2 p.m. EDT. 

The participants are:

Dr. Aaron Burton, NASA Johnson Space Center, Planetary Scientist and Principal Investigator

Dr. Sarah Castro-Wallace, NASA Johnson Space Center, Microbiologist and Project Manager

Dr. David J. Smith, NASA Ames Research Center, Microbiologist

Dr. Mark Lupisella, NASA Goddard Space Flight Center, Systems Engineer

Dr. Jason P. Dworkin, NASA Goddard Space Flight Center, Astrobiologist

Dr. Christopher E. Mason, Weill Cornell Medicine Dept. of Physiology and Biophysics, Associate Professor

Kate Rubins’ Space Station Science Scrapbook

As a child, Kate Rubins dreamed of being an astronaut and a scientist. During the past four months aboard the International Space Station, that dream came full circle. She became the first person to sequence DNA in space, among other research during her recent mission, adding to her already impressive experience. She holds a doctorate in molecular biology, and previously led a lab of 14 researchers studying viruses, including Ebola.

Here’s a look back at Rubins in her element, conducting research aboard your orbiting laboratory.

Kate inside Destiny, the U.S. Laboratory Module

The U.S. national laboratory, called Destiny, is the primary research laboratory for U.S. payloads, supporting a wide range of experiments and studies contributing to health, safety, and quality of life for people all over the world. 

Destiny houses the Microgravity Science Glovebox (MSG), in which Kate worked on the Heart Cells experiment.

Swabbing for Surface Samples

Microbes that can cause illness could present problems for current and future long duration space missions. 

Understanding what microbe communities thrive in space habitats could help researchers design antimicrobial technology. Here, Kate is sampling various surfaces of the Kibo module for the Microbe-IV investigation.

Culturing Beating Heart Cells in Space

The Heart Cells investigation uses human skin cells that are induced to become stem cells, which can then differentiate into any type of cell. 

Researchers forced the stem cells to grow into human heart cells, which Rubins cultured aboard the space station for one month.

Rubins described seeing the heart cells beat for the first time as “pretty amazing. First of all, there’s a few things that have made me gasp out loud up on board the [space] station. Seeing the planet was one of them, but I gotta say, getting these cells in focus and watching heart cells actually beat has been another pretty big one.”

Innovative Applied Research Experiment from Eli Lilly

The Hard to Wet Surfaces investigation from Eli Lilly, and sponsored by the Center for the Advancement of Science in Space (CASIS), looks at liquid-solid interactions and how certain pharmaceuticals dissolve, which may lead to more potent and effective medicines in space and on Earth. 

Rubins set up vials into which she injected buffer solutions and then set up photography to track how tablets dissolved in the solution in microgravity.

Capturing Dragon

Rubins assisted in the capture of the SpaceX Dragon cargo spacecraft in July. The ninth SpaceX resupply mission delivered more than two thousand pounds of science to the space station. 

Biological samples and additional research were returned on the Dragon spacecraft more than a month later.  

Sliding Science Outside the Station

Science doesn’t just happen inside the space station. External Earth and space science hardware platforms are located at various places along the outside of the orbiting laboratory. 

The Japanese Experiment Module airlock can be used to access the JEM Exposed Facility. Rubins installed the JEM ORU Transfer Interface (JOTI) on the JEM airlock sliding table used to install investigations on the exterior of the orbiting laboratory.

Installing Optical Diagnostic Instrument in the MSG

Rubins installed an optical diagnostic instrument in the Microgravity Science Glovebox (MSG) as part of the Selective Optical Diagnostics Instrument (SODI-DCMIX) investigation. Molecules in fluids and gases constantly move and collide. 

When temperature differences cause that movement, called the Soret effect, scientists can track it by measuring changes in the temperature and movement of mass in the absence of gravity. Because the Soret effect occurs in underground oil reservoirs, the results of this investigation could help us better understand such reservoirs.

The Sequencing of DNA in Space

When Rubins’ expedition began, DNA had never been sequenced in space. Within just a few weeks, she and the Biomolecule Sequencer team had sequenced their one billionth “base” – the unit of DNA - aboard the orbiting laboratory. 

The Biomolecule Sequencer investigation seeks to demonstrate that DNA sequencing in microgravity is possible, and adds to the suite of genomics capabilities aboard the space station.

Studying Fluidic Dynamics with SPHERES

The SPHERES-Slosh investigation examines the way liquids move inside containers in a microgravity environment. The phenomena and mechanics associated with such liquid movement are still not well understood and are very different than our common experiences with a cup of coffee on Earth.

Rockets deliver satellites to space using liquid fuels as a power source, and this investigation plans to improve our understanding of how propellants within rockets behave in order to increase the safety and efficiency of future vehicle designs. Rubins conducted a series of SPHERES-Slosh runs during her mission.

Retrieving Science Samples for Their Return to Earth

Precious science samples like blood, urine and saliva are collected from crew members throughout their missions aboard the orbiting laboratory. 

They are stored in the Minus Eighty-Degree Laboratory Freezer for ISS (MELFI) until they are ready to return to Earth aboard a Soyuz or SpaceX Dragon vehicle.

Measuring Gene Expression of Biological Specimens in Space

Our WetLab-2 hardware system is bringing to the space station the technology to measure gene expression of biological specimens in space, and to transmit the results to researchers on Earth at the speed of light. 

Rubins ran several WetLab-2 RNA SmartCycler sessions during her mission.

Studying the First Expandable Habitat Module on the Space Station

The Bigelow Expandable Activity Module (BEAM) is the first expandable habitat to be installed on the space station. It was expanded on May 28, 2016. 

Expandable habitats are designed to take up less room on a spacecraft, but provide greater volume for living and working in space once expanded. Rubins conducted several evaluations inside BEAM, including air and surface sampling.

Better Breathing in Space and Back on Earth

Airway Monitoring, an investigation from ESA (the European Space Agency), uses the U.S. airlock as a hypobaric facility for performing science. Utilizing the U.S. airlock allows unique opportunities for the study of gravity, ambient pressure interactions, and their effect on the human body. 

This investigation studies the occurrence and indicators of airway inflammation in crew members, using ultra-sensitive gas analyzers to evaluate exhaled air. This could not only help in spaceflight diagnostics, but that also hold applications on earth within diagnostics of similar conditions, for example monitoring of asthma.

Hot Science with Cool Flames

Fire behaves differently in space, where buoyant forces are removed. Studying combustion in microgravity can increase scientists’ fundamental understanding of the process, which could lead to improvement of fire detection and suppression systems in space and on Earth. 

Many combustion experiments are performed in the Combustion Integration Rack (CIR) aboard the space station. Rubins replaced two Multi-user Droplet Combustion Apparatus (MDCA) Igniter Tips as part of the CIR igniter replacement operations.

Though Rubins is back on Earth, science aboard the space station continues, and innovative investigations that seek to benefit humans on Earth and further our exploration of the solar system are ongoing. Follow @ISS_Research to keep up with the science happening aboard your orbiting laboratory.  

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com

Scientists find another sign suggesting life existed on Mars

According to new research published in the Journal of Geophysical Research, scientists are getting even more indicators that life once existed on Mars. The latest proof? Carbonates found in 3.8 billion-year-old rock in the Huygens basin.

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First flower ever grown in space bloomed today!

Creepy or adorable? Researchers at Harvard University have demonstrated the first autonomous, untethered, entirely soft robot: the octobot.

Instead of being controlled by electronics, the robot’s logic board is powered by chemical reactions and fluid passing along tiny channels. Scientist have struggled to create completely soft robots because rigid components like circuit boards, power sources and electronic controls are difficult to replace.  

Learn more about the octobot and soft robotics here and see the full study published in Nature here.

Videos Credit: Harvard SEAS/Image Credit Lori Sanders

Solar System: Things to Know This Week

In addition to the Mercury transit of the sun today, there are a few other things you should know about our solar system this week:

1. Mars, Ready for its Close-Up

Mars will soon be closer to Earth than it has been for 11 years, presenting a great opportunity for backyard sky watchers.

2. Fire and Ice

Our spacecraft have an even closer view of Mars, and that fact regularly leads to some intriguing discoveries. The latest: volcanoes may have erupted beneath an ice sheet there billions of years ago. The above image is a mineral map of part of the Martian surface.

3. Icy Hydra

Meanwhile, our New Horizons spacecraft has sent home the first compositional data about Pluto’s four small moons. The new data show the surface of Hydra is dominated by nearly pristine water ice–confirming hints that scientists picked up in images showing Hydra’s highly reflective surface.

4. Ceres, Ever Sharper

The mission director for our Dawn mission writes, “Ceres, which only last year was hardly more than a fuzzy blob against the stars, is now a richly detailed world, and our portrait grows more elaborate every day.”

5. Join us at Jupiter

Our Juno mission arrives at the giant planet on Jul. 4. Meanwhile, all amateur astronomers are invited to take part in a worldwide effort to identify potential observations for the spacecraft to make once it’s in orbit. Find out how to join HERE.

Want to learn more? Read our full list of the 10 things to know this week about the solar system HERE.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com

Astronauts wanted

(Image credit: NASA/KSC)

NASA’s retro guide to future living over on CNN

Dynamic projection mapping onto deforming non-rigid surface

Truly impressive technology from Ishikawa Watanabe Laboratory, University of Tokyo, can accurately projection map on moving, loose, dynamic surfaces:

We realize dynamic projection mapping onto deforming non-rigid surface based on two original technologies. The first technology is a high-speed projector “DynaFlash” that can project 8-bit images up to 1,000 fps with 3 ms delay. The second technology is a high-speed non-rigid surface tracking at 1,000 fps. Since the projection and sensing are operated at a speed of 1,000 fps, a human cannot perceive any misalignment between the dynamically-deforming target and the projected images. Especially, focusing on new paradigms in the field of user interface and fashion, we have demonstrated dynamic projection mapping onto a deformed sheet of paper and T-shirt. Also we show that projection to multiple targets can be controlled flexibly by using our recognition technique. 

More Here