Denkeschon - /shittypoem

Some relaxing short videos I took to help with sleep or calming ଘ(੭*ˊᵕˋ)੭* ☆彡

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You hate yourself so loudly. You hate yourself at the top of your lungs. Your loathing for yourself permeates your speech. “Sorry I’m just rambling.” “Don’t worry about it.” “Just ignore me.” “Sorry if I’m annoying you.” “Sorry I don’t make sense.” “Sorry about that.” Sorry, sorry, sorry. You act as if you have to beat everyone else to the punch. As if the punching bag is you. If you hate yourself first, if you hate yourself loudest, then nobody will hurt you. You clapped your hands over your ears and shut your eyes and balled yourself up so that you’d never have to experience people’s loathing for you. And it meant you never heard their love. You drowned it out. You screamed your hatred over it. And you never got to hear it. 

Mewkledreamy stickers are available in my shop 💗

It is hard to be alone.

It is hard to do things by yourself it it is mostly hard to find a reason to keep going on when you're by yourself. I guess most of us pass our lives basing our happiness on other people. We put all our hopes and expectations of happiness and personal realization on other people.

"I am happy because I have you by my side"

"You are the reason why I am still going on and fighting for things"

"You are my inspiration"

It is never yourself. It is definitely never your own straight. How to change that?

𝖗𝖆𝖙𝖘 𝖎

Cure Peace

♡ ♡ ♡ ~ ♡ ♡ ♡ ~ ♡ ♡ ♡

Requested by anon

There’s some little aspects about myself that I am not quite sure about how they are configured. Are they a trace of being what is medically called ‘’being crazy’’ or are they just what we should all call ‘’having a different brain function’’? 

It is so hard to talk to people about it because I guess society is still working on the top of older parameters of judging and thinking. On my point of view, maybe we are all this time calling people “weird”, “crazy” or “mental” but in the end they are just bright and manage to see things on a different way. 

Think about how many myths around the functionality of our brain we are currently still spreading. For example, we don`t use only 10% of the brain, we also don’t have any evidence of the existence of right-brained or left-brained people. 

My point is: We are probably excluding some people from society based on how their thinking process is when they are probably very useful and might be able to do and see what is missing on this world.

Танцы. 1963. Якобсон Александра Николаевна (1903-1966)

Scientists Explore Links Between Genetics, Gut Microbiome and Memory

A new study is among the first to trace the molecular connections between genetics, the gut microbiome and memory in a mouse model bred to resemble the diversity of the human population.

While tantalizing links between the gut microbiome and brain have previously been found, a team of researchers from two U.S. Department of Energy national laboratories found new evidence of tangible connections between the gut and the brain. The team identified lactate, a molecule produced by all species of one gut microbe, as a key memory-boosting molecular messenger. The work was published in the journal BMC Microbiome.

“Our study shows that the microbiome might partner with genetics to affect memory,” said Janet Jansson, a microbial ecologist at Pacific Northwest National Laboratory and a corresponding author of the study.

Scientists know that mice which have been fed microbes that benefit health, called probiotics, experience several positive benefits. Scientists also know that microbes produce molecules that travel through the blood and act as chemical messengers that influence other parts of the body, including the brain. However, it wasn’t clear which specific microorganisms and microbial molecular messengers might influence memory until now.

(Image caption: Lactobacillus, a common probiotic, grow in a petri dish. Credit: Rattiya Thongdumhyu | Shutterstock.com)

“The challenge is that a mouse’s unique genetic makeup and environmental conditions also impact its memory and microbiome,” said Antoine Snijders, a bioscientist at Lawrence Berkeley National Laboratory (Berkeley Lab) and co-corresponding author. “To know if a microbial molecule influenced memory, we needed to understand the interaction between genetics and the microbiome.”

The microbiome’s impact on memory is a very active research area now, he added, with more than 100 papers published in the last five years on links between common probiotics and memory.

Mouse genetics influence memory and gut microbiome

Before they could start hunting for molecules that might be involved with memory improvement, Jansson, Snijders and their colleagues needed to determine how genetics influence memory.

The researchers started with a collection of mice called the Collaborative Cross. They bred 29 different strains of mice to mimic the genetic and physical diversity of a human population. It includes mice of different sizes, coat colors and disposition (e.g., timid or bold). Researchers also know the genome sequences of each strain.

First, the team gave each strain of mice a memory test. Then they screened each strain for genetic variations and correlated these variations to the memory results. They found two sets of genes associated with memory. One was a set of new candidate genes for influencing cognition, while the other set of genes was already known.

Next, the researchers analyzed the gut microbiome of each strain so they could make microbial connections to the genetics and memory links they already had. They identified four families of microbes that were associated with improved memory. The most common of those was a species of Lactobacillus, L. reuteri.

(Image caption: An illustration of nerve cells in the hippocampus, the region of the brain linked to memory formation. Credit: Kateryna Kon | Shutterstock.com)

To test this association, the researchers fed L. reuteri to germ-free mice without any gut microbes and then tested the mice’s memory. They saw a significant improvement relative to germ-free mice not fed microbes. They also found the same improvement when they fed germ-free mice one of two other Lactobacillus species.

“While a link between Lactobacillus and memory was previously reported, we also found it independently in this unbiased genetic screen,” Snijders said. “These results suggest that genetic variation in large part controls memory, as well as the differences in the composition of the gut microbiome across strains.”

Diet and probiotics boost memory

Finally, the researchers wanted to identify which microbe-related molecules might be involved with memory enhancement. They analyzed stool, blood and brain tissue from germ-free mice each fed a specific species of Lactobacillus. Lactate was one of the common metabolic molecular byproducts; it is also a molecule that all Lactobacillus strains produce.

The team fed lactate to mice previously identified to have poor memory and noticed that their memory improved. Mice fed lactate or Lactobacillus microbes also had increased levels of gamma-aminobutyric acid (GABA), a molecular messenger linked to memory formation in their brains.

To see if the same molecular mechanism might apply in humans too, the researchers contacted Paul Wilmes, at the University of Luxembourg, who developed a tiny chip that mimics where microbes interact with human intestinal tissue. When Wilmes and his colleagues tested L. reuteri in this chip, they saw that lactate produced by the microbes traveled through the human gut tissue, indicating that it could enter the bloodstream and potentially travel to the brain.

“While this research strengthens the idea that diet, genetics, and behaviors—like memory—are connected, further work is needed to show if Lactobacillus can improve memory in humans,” Jansson said.

Snijders agreed, adding that it might be possible one day to use probiotics to improve memory in targeted populations, such as people with learning disabilities and neurodegenerative disorders.

So I’m in love with the Tropical Rouge Cure designs, especially Cure Summer.